Biotin-ProTx-I - Ion Channels and Transporters
Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. Biotin-ProTx-I is a biotin-tagged version of ProTx-I.
Technical specification
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Sequence : | Biotin-ECRYWLGGCSAGQTCCKHLVCSRRHGWCVWDGTFS-OH (Cys2-Cys16; Cys9-Cys21; Cys15-Cys25) |
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MW : | 3987.50 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| PTB001-0.1 mg | 0.1 mg | 385€ | 462$ |
| PTB001-0.5 mg | 0.5 mg | 1155€ | 1386$ |
If you'd like to learn more about this toxin, visit our product page on our Smartox website—Our sister company specializing in the synthesis of complex toxins.
