GsAF-1 - Ion Channels and Transporters
GsAF-1 (also termed β-theraphotoxin-Gr1b, GsAF-I) was originally isolated from the venom of Grammostola rosea spider. GsAF-I peptide toxin is reported to block the following voltage-gated sodium channel isoforms: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with respective IC50 values of 0.4, 0.6, 1.3, 0.3, 1.2 and 0.04 µM. In addition, the toxin blocks the hERG1 isoform with an IC50 value of 4.8 µM.
Technical specification
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Sequence : | H-YCQKWLWTCDSERKCCEDMVCRLWCKKRL-NH2 (Cys2-Cys16; Cys9-Cys21; ; Cys15-Cys25) |
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MW : | 3105.58 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 12GSF001-0.1 mg | 0.1 mg | 220€ | 264$ |
| 12GSF001-0.5 mg | 0.5 mg | 660€ | 792$ |
| 12GSF001-1 mg | 1 mg | 1045€ | 1254$ |
If you'd like to learn more about this toxin, visit our product page on our Smartox website—Our sister company specializing in the synthesis of complex toxins.
