GsAF-2 - Ion Channels and Transporters
GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.
Technical specification
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Sequence : | H-YCQKWMWTCDEERKCCEGLVCRLWCKKKIEW-OH (Cys2-Cys16; Cys9-Cys21; ; Cys15-Cys25) |
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MW : | 3201.54 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 12GSF002-0.1 mg | 0.1 mg | 220€ | 264$ |
| 12GSF002-0.5 mg | 0.5 mg | 660€ | 792$ |
| 12GSF002-1 mg | 1 mg | 1045€ | 1254$ |
If you'd like to learn more about this toxin, visit our product page on our Smartox website—Our sister company specializing in the synthesis of complex toxins.
