IRS-1 substrate - Growth Factors and Cytokines
Insulin receptor (IR) substrate 1 (IRS-1) peptide is a highly selective substrate for certain kinase sub-families- such as receptor tyrosine kinases (which includes IR). IRS-1 is also a very good substrate for the cytoplasmic kinases JAK-1, 2, and 3. IRS-1 is a large ubiquitously expressed protein, vital for propagating insulin action. IRS-1 is activated by phosphorylation of multiple tyrosine residues via an activated IR. Activated IRS-1 then acts as a docking site for downstream signalling proteins which contain a Src homology 2 (SH2) domain (such as phosphatidylinositol 3-kinase (PI3K), growth factor receptor-bound protein 2 (Grb2), and SHP-2). In addition to its role in metabolic signalling, IRS-1 also propagates proliferative and anti-apoptotic signals and is overexpressed in most cancers.
Technical specification
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Sequence : | H-CKKSRGDYTMQIG-OH |
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MW : | 1.616.7 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| CRB1000959-0.5 mg | 0.5 mg | 141€ | 170$ |
| CRB1000959-1 mg | 1 mg | 193€ | 232$ |
| CRB1000959-5 mg | 5 mg | 533€ | 640$ |
| CRB1000959-10 mg | 10 mg | 815€ | 978$ |
| CRB1000959-25mg | 25mg | 1111€ | 1334$ |
