NMB-1 - Ion Channels and Transporters
NMB-1 (Noxious mechanosensation blocker 1) is an analogue of a peptide isolated from a marine conesnail. This 19 amino acid peptide has shown a 30 fold selectivity in inhibiting slowly adapting mechanically activated currents over rapidly adapting ones. It is an interesting tool to distinguish between RA and SA currents. NMB-1 significantly blocks SA currents at 1 µM in sensory neurons contrary to GsMTx4. Some results suggest that NMB-1 could also block mechanosensitive ion channels in cochlear hair cells at 5 µM.
Smartox Biotechnology is pleased to be the first company offering this research tool.
Technical specification
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Sequence : | H-FNWRCCLIPCRRNHKKFFC-OH (Cys5-Cys19; Cys6-Cys10) |
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MW : | 2467.03 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| NMB001-0.1 mg | 0.1 mg | 149€ | 179$ |
| NMB001-0.5 mg | 0.5 mg | 429€ | 515$ |
| NMB001-1 mg | 1 mg | 605€ | 726$ |
If you'd like to learn more about this toxin, visit our product page on our Smartox website—Our sister company specializing in the synthesis of complex toxins.
