TAMRA-ShK - Ion Channels and Transporters
TMR-ShK is a fluorescent (red) derivative of the well-known ShK toxin (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently Kv1.3 (KCNA3), Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) with a Kd value of 11 pM, 16 pM, 312 pM and 165 pM, respectively. The fluorescent TMR-labeled ShK blocks Kv1.3 and Kv1.1 with Kd values of 52 pM and 397 pM, respectively. TMR-ShK can be used to identify lymphocytes expressing Kv1.3 channels such as effective memory T cells (TEM) in the case of autoimmune diseases (type 1 diabetes, mellitus or rheumatoid arthritis) which overexpress Kv1.3 channels.
Technical specification
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Sequence : | H-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC-OH (Cys3-Cys35; Cys12-Cys28; Cys17-Cys32) |
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MW : | 4054.78 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| SAT001-0.1 mg | 0.1 mg | 330€ | 396$ |
| SAT001-0.5 mg | 0.5 mg | 1155€ | 1386$ |
| SAT001-1 mg | 1 mg | 1964€ | 2357$ |
If you'd like to learn more about this toxin, visit our product page on our Smartox website—Our sister company specializing in the synthesis of complex toxins.
