Biotin HER-2 substrate peptide – Biotin Labeled

Human epidermal growth factor receptor (HER-2)/epidermal growth factor receptor-2 (ErbB-2), is a key receptor linked to metastasis in tumours. The oncogenic ErbB-2 receptor has intrinsic receptor tyrosine kinase (RTK) activity, the receptor is activated by ligand binding which induces receptor dimerization. These RTK complexes can activate mitogen-activated protein kinase (MAPK) and phosphoinositol 3-kinase (PI3K)/Akt pathways. This peptide has been identified as a substrate for HER-2/ErbB-2 as it is phosphorylated upon receptor activation and therefore acts as a marker for receptor activation in kinases assays. Contains a covalently attached N-terminal biotin tag for convenient detection and purification.

 

Technical specification

 KD20 peptide Sequence : Biot-GGMEDIYFEFMGGKKK-NH2
 KD20 peptide MW : 2.062.44 g/mol
 KD20 peptide Purity : > 95%
 KD20 peptide Counter-Ion : TFA Salts
Peptide library synthesis KD20 peptide Delivery format : Lyophilized

Price

 

Product Size Price € Price $
CRB1000260-1 mg 1 mg 252€ 303$

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