EGFR/kinKDR peptide substrate - Growth Factors and Cytokines

Substrate of the epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase family known as ErbBs or HER receptors. These receptors are involved in the regulation of cell proliferation, survival, differentiation and migration. However their dysregulation can contribute towards many diseases such as cancer. Binding to the ligand binding domain of the EGFR causes receptor dimerization. This is sequentially followed by the tyrosine kinase domain being activated and the tyrosines on the C-terminal tail become phosphorylated, which in turn activates downstream signalling pathways.