GaTx2 – Ion Channels and Transporters

GaTx2 (gating modifier of anion channels 2) was isolated from the venom of Leiurus quinquestriatus hebraeus. GaTx2 is the most potent peptide inhibitor of ClC-2 (CLCN2) chloride channel ever described. Kd value is close to 20 pM. GaTx2slows ClC-2 activation but without altering channel conductance. The effect is voltage-dependent. This inhibitory effect was highlighted on rabbit ClC-2 channels expressed in oocytes. It has no effect on ClC-0, ClC-1, ClC-3, ClC-4, CFTR, GABAC, Xenopus ClCa, Shaker B or Kv1.2 channels. Structurally, GaTx2 is composed of two β-strands and one α-helix.This peptide is also called Leiuropeptide II. Bears 89, 93 and 96% identity with OdK1, neurotoxin PO1 and leiuropeptide III, respectively.

Technical specification

	Sequence :	H-VSCEDCPDHCSTQKARAKCDNDKCVCEPI-OH (Cys3-Cys19; Cys6-Cys24; ; Cys10-Cys26)
	MW :	3191.25 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
10GTX002-0.1 mg	0.1 mg	220€	264$
10GTX002-0.5 mg	0.5 mg	715€	858$
10GTX002-1 mg	1 mg	1100€	1320$

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GaTx2 – Ion Channels and Transporters

Technical specification

Price

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