ShK – Stichodactyla toxin - Ion Channels and Transporters
ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM
Technical specification
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Sequence : | H-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC-OH (Cys3-Cys35; Cys12-Cys28; Cys17-Cys32) |
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MW : | 4054.78 g/mol |
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Purity : | > 95% |
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Counter-Ion : | TFA Salts |
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Delivery format : | Lyophilized |
Price
| Product | Size | Price € | Price $ |
| 08SHK001-0.1 mg | 0.1 mg | 132€ | 159$ |
| 08SHK001-0.5 mg | 0.5 mg | 413€ | 496$ |
| 08SHK001-5 x 0.01 mg | 5 x 0.01 mg | 110€ | 132$ |
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