ShK – Stichodactyla toxin – Ion Channels and Transporters

ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM

Technical specification

	Sequence :	H-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC-OH (Cys3-Cys35; Cys12-Cys28; Cys17-Cys32)
	MW :	4054.78 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized

Price

Product	Size	Price €	Price $
08SHK001-0.1 mg	0.1 mg	132€	159$
08SHK001-0.5 mg	0.5 mg	413€	496$
08SHK001-5 x 0.01 mg	5 x 0.01 mg	110€	132$

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