ShK – Stichodactyla toxin – Ion Channels and Transporters

ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent potassium channels. It blocks Kv1.3 (KCNA3) potently and also Kv1.1 (KCNA1), Kv1.4 (KCNA4) and Kv1.6 (KCNA6) respectively with a Kd of 11 pM, 16 pM, 312 pM and 165 pM. Interestingly, it was also demonstrated that ShK potently inhibits the hKv3.2b channel with an IC50 value of approximately 0.6 nM

 

Technical specification

 KD20 peptide Sequence : H-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC-OH (Cys3-Cys35; Cys12-Cys28; Cys17-Cys32)
 KD20 peptide MW : 4054.78 g/mol
 KD20 peptide Purity : > 95%
 KD20 peptide Counter-Ion : TFA Salts
Peptide library synthesis KD20 peptide Delivery format : Lyophilized

Price

 

Product Size Price € Price $
08SHK001-0.1 mg 0.1 mg 132€ 159$
08SHK001-0.5 mg 0.5 mg 413€ 496$
08SHK001-5 x 0.01 mg 5 x 0.01 mg 110€ 132$

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