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HIV-1 Rev (34-50)

HIV-1 Rev (34-50) – Other Categories The full Rev is vital in aiding transport of unspliced viral mRNA from the nucleus. Within Rev there are 3 main functional regions – the arginine rich motif (ARM), the oligomerization domain (OD), and nuclear export...

Enfuvirtide (T-20)

Enfuvirtide (T-20) – Other Categories Currently, enfuvirtide (T-20) is the only available membrane fusion inhibitor licensed for HIV-1 combination therapy. T-20 was designed to bind the HIV-1 gp41 peptide preventing viral formation and membrane fusion. The...

C-telopeptide

C-telopeptide – Other Categories C-terminal telopeptide is produced when type I collagen in the bone is degraded and so released into the blood. Within collagen structure, made up of a triple helix of 3 amino acid chains, C-telopeptide is located at the...

KRREILSRRPSYR-acid

KRREILSRRPSYR-acid – Other Categories Protein kinases are important drug targets for numerous diseases to try and better evaluate the enzyme specificity, affinity, mode of action and identify possible inhibitors. In vitro assays and synthetic substrates provide...

N-L-Glutamyl-L-Lysine

N-L-Glutamyl-L-Lysine – Other Categories The human oligopeptide transporter (PEPT1) is a critical transporter of dipeptides, tripeptides, and peptide-like drugs, including β-lactam and cephalosporin antibiotics, and ACE inhibitors. Therefore, there is an effort...