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PAR-1 Antagonist

PAR-1 Antagonist – GPCR Modulators YFLLRNP works as a partial PAR-1 agonist that induces platelet shape change without calcium mobilization via the galpha12/13 signalling cascade. Full activation of platelets is only achieved at higher concentrations. YFLLRNP...

PAR-3 Agonist (Mouse)

PAR-3 Agonist (Mouse) – GPCR Modulators Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to...

PAR-3 Agonist (Human)

PAR-3 Agonist (Human) – GPCR Modulators Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to...

PAR-4 Agonist (Mouse)

PAR-4 Agonist (Mouse) – GPCR Modulators Thrombin is the main effector of the coagulation cascade- it is a serine protease. Thrombin binds to active protease activated receptor (PAR) which belongs to a subfamily of G-protein coupled receptors (GPCR). Thrombin...

PAR-4 Agonist (Human)

PAR-4 Agonist (Human) – GPCR Modulators Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to...