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Antigen peptides

Tumor-associated antigens (TAAs) act as target peptides to induce cytotoxic T lymphocyte (CTL) responses for the development of cancer vaccines, a promising approach for cancer immunotherapy.
Tumor-associated antigens are selected based on their, immunogenicity, role in oncogenicity, number of antigenic epitopes and their expression level in antigen-positive cancer cells1.
Receptors of CD8+ T cells usually recognize antigenic peptides presented in association with MHC class I molecules. Peptides displayed on the HLA-A*0201 molecules are the most frequently used since this HLA allele (HLA-A group, MHC class I) is expressed by 45% of the human population and the peptide binding motifs are well-charaterized1.
To validate the efficacy of a tumor-associated antigen as a T-cell epitope, CD8+ T cells are usually induced in vitro using peptide-pulsed dendritic cells (DCs), generated from peripheral blood mononuclear cells (PBMCs), as antigen-presenting cells (APCs). Upon primary in vitro immunization, peptide-responding T cells are analyzed for their capacity to recognize tumor cell lines expressing the candidate tumor-associated antigen and to trigger an antigen-specific and HLA-A*02-restricted cytolytic activity against the target tumor cells. This approach is nammed reverse immunology. It has been successfully used to identify several antigenic peptides that are recognized by CD4+ or CD8+ T lymphocytes.
Tumour-associated antigens that have the potential to elicit immune responses are classified into different categories2 :

  • Antigens of high tumoural specificity
    Antigens derived from oncogenic viruses
    Antigens encoded by mutated genes
    Antigens encoded by cancer-germline genes
  • Antigens of low tumoural specificity
    Tissue/Lineage-restricted differentiation antigens
    Antigens derived from overexpressed proteins

 

Name Description Catalog # More details
Melan-A / MART1 (26-35) peptide – EAAGIGILTV Tumor-associated antigen peptide SB026 Click here
MUC1 (12-20) peptide – LLLLTVLTV Tumor-associated antigen peptide SB027 Click here
OVA 257-264 – SIINFEKL Tumor-associated antigen peptide SB031 Click here
TRP-2 Peptide (180-188) – SVYDFFVWL Tumor-associated antigen peptide SB033 Click here
PADRE peptide – AKFVAAWTLKAAA Tumor-associated antigen peptide SB054 Click here
A*02:01/Human Survivin (96-104) – LTLGEFLKL Tumor-associated antigen peptide SB055 Click here
FluM1 (58-66) – GILGFVFTL Tumor-associated antigen peptide SB056 Click here
HIV-1 p17 Gag (77-85) – SLYNTVATL Tumor-associated antigen peptide SB057 Click here
HCV NS5B (2594-2602) – ALYDVVTKL Tumor-associated antigen peptide SB058 Click here
Ova (323-339) – ISQAVHAAHAEINEAGR Tumor-associated antigen peptide SB059 Click here
CD20 (188-196) – SLFLGILSV Tumor-associated antigen peptide SB060 Click here
CMV pp65 (120-129) – MLNIPSINV Tumor-associated antigen peptide SB061 Click here
NY-ESO-1 (157-165) – SLLMWITQV Tumor-associated antigen peptide SB062 Click here
NY-ESO-1 (123-137) DRB1*04:01 – LKEFTVSGNILTIRL Tumor-associated antigen peptide SB063 Click here
MAGE-A1 (278-286) – KVLEYVIKV Tumor-associated antigen peptide SB064 Click here
HER-2/neu (85-94) – LIAHNQVRQV Tumor-associated antigen peptide SB065 Click here
A*02:01/Human Survivin (LMLGEFLKL) Tumor-associated antigen peptide SB066 Click here
MAGE-A p248V9 – YLEYRQVPV Tumor-associated antigen peptide SB067 Click here
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) Tumor-associated antigen peptide SB068 Click here
EBV BMLF1 (280-288) – GLCTLVAML Tumor-associated antigen peptide SB069 Click here
MAGE-A2 (157-166) – YLQLVFGIEV Tumor-associated antigen peptide SB070 Click here
CMV pp65 (113-121) – VYALPLKML Tumor-associated antigen peptide SB071 Click here
OVA 257-264 scrambled Tumor-associated antigen peptide SB073 Click here
Biotin-FluM1 (58-66) Tumor-associated antigen peptide SB074 Click here
Biotin-Ova (323-339) Tumor-associated antigen peptide SB075 Click here
Biotin-NY-ESO-1 (157-165) Tumor-associated antigen peptide SB076 Click here
Biotin-MAGE-A1 (278-286) Tumor-associated antigen peptide SB077 Click here
Biotin-MAGE-A2 (157-166) Tumor-associated antigen peptide SB078 Click here
NY-ESO-1 (157-165) scrambled Tumor-associated antigen peptide SB079 Click here
MAGE-A p248V9 scrambled Tumor-associated antigen peptide SB080 Click here
Melan-A/MART 1 (26-35) scrambled Tumor-associated antigen peptide SB081 Click here
MAGE-A2 (157-166) scrambled Tumor-associated antigen peptide SB082 Click here
MAGE-A1 (278-286) scrambled Tumor-associated antigen peptide SB083 Click here
PADRE scrambled Tumor-associated antigen peptide SB084 Click here
KD20 peptide SB113 Click here