Peptide click chemistry

What a great news for us to know that The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2022 to

Carolyn R. Bertozzi
Stanford University, CA, USA

Morten Meldal
University of Copenhagen, Denmark

K. Barry Sharpless
Scripps Research, La Jolla, CA, USA

“for the development of click chemistry and bioorthogonal chemistry”

SB-PEPTIDE is using click-chemistry for many years in routine to conjugate a wide range of compounds (fluorescent dyes, biotin, metal chelators…) to peptides and other biologics (bio-conjugation service). This amazing selective conjugation reaction allows to circuvment some limitations with other reaction such as thiol/maleimide, amine reactions…

This discovery has been a major breakthrough in bioconjugation which allows the development valuable drugs.

Press release : Nobel prize 2022

Nobel prize 2022 press release

Bioconjugation service

SB-PEPTIDE is performing in routine all kind of bio-conjugations for many years on peptides as well as proteins, oligonucleotides, PNAs, single domain antibodies (sdAb), scFv and antibodies. The company is fully equiped with purification (RP-HPLC, SEC-HPLC) and analytical systems (LCMS, LCMSMS).

SB-PEPTIDE can conjugate a wide range of compounds including fluorescent dyes, biotin and desthiobiotin, metal chelators (DOTA, NOTA, Ruthenium cages), fatty acids, cytotoxic payloads.

It can also conjugate several biologics together to form homodimers or heterodimers of peptides, peptide-oligonucleotides conjugates…

SB-PEPTIDE can help clients to define the best conjugation strategy so please get in touch