Acetyl Octapeptide-3

Neurotransmitter Inhibitor

Acetyl Octapeptide-3 (SNAP-8) is an 8-amino acid extension of Argireline featuring two additional C-terminal residues (Ala-Asp), providing enhanced SNAP-25 competitive inhibition with greater binding efficiency at the SNARE complex. Clinical formulation studies suggest wrinkle depth reductions with regular use. Particularly effective on deep expression lines and forehead creases. Used in premium anti-aging serums and targeted wrinkle treatment concentrates.

Main characteristics

Acetyl Octapeptide-3 shares Argireline's mechanism of competing with the N-terminal domain of SNAP-25 for integration into the SNARE complex, but the two additional residues improve the fit and duration of competitive binding. It is stable at pH 4.5–7.0 and compatible with most serum and cream bases. Often combined with Argireline for complementary coverage of the SNARE complex inhibition. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Premium anti-wrinkle serums targeting deep expression lines
Forehead and periorbital wrinkle treatments
Combination formulas with Argireline for dual-mechanism botox-like effect
Research on SNARE complex dynamics and neuromuscular peptide inhibitors

Technical specification

	Sequency :	Ac-EEMQRRAD-NH2
	INCI name	Acetyl Octapeptide-3
	MW :	1074.49 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	868844-74-0

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB351-20mg	20 mg	271.32	325.58
SB351-50mg	50 mg	406.98	488.38
SB351-100mg	100 mg	542.64	651.17
SB351-500mg	500 mg	1058.15	1269.78

For more information about Cosmetic Peptides, please visit our dedicated page.

Explore our Cosmetic Catalog products. Click HERE to discover additional reference compounds.

Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

Submit a Custom Request

Get a Quote