Decapeptide-12

Tyrosinase-inhibiting depigmenting peptide for dark spot reduction and skin tone uniformity

Decapeptide-12 is a 10-amino acid peptide tyrosinase inhibitor that reduces melanin biosynthesis by interfering with the enzymatic activity of tyrosinase, the main enzyme in the melanin production pathway. It provides skin brightening and tone-uniformity benefits as a safe alternative to hydroquinone and kojic acid, without associated cytotoxic risk. It can be combined with Nonapeptide-1 for a dual-mechanism depigmenting approach.

Main characteristics

Decapeptide-12 acts directly on tyrosinase enzymatic activity, reducing the conversion of tyrosine to DOPA and subsequently to melanin, without affecting melanocyte cell viability. This selective mechanism offers excellent safety and tolerability. Stable in aqueous formulations at pH 4.5–7.0. Compatible with vitamin C, niacinamide, and other brightening actives for synergistic effect. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Brightening serums and creams targeting dark spots and hyperpigmentation
Melasma and post-inflammatory hyperpigmentation (PIH) treatments
Skin tone uniformity formulations for Asia-Pacific markets
Hydroquinone-free alternative brightening products
Research in melanogenesis inhibition and tyrosinase pharmacology

Technical specification

	Sequency :	H-YRSRKYSSWY-OH
	INCI name	Decapeptide-12
	MW :	1394.67 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	137665-91-9

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB360-20mg	20 mg	288.02	345.62
SB360-50mg	50 mg	432.02	518.43
SB360-100mg	100 mg	576.03	691.24
SB360-500mg	500 mg	1123.26	1347.92

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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