Palmitoyl Hexapeptide-12

Signal hexapeptide for elastin synthesis and skin firmness

Palmitoyl Hexapeptide-12 (Biopeptide EL®) is the lipidated form of the elastin-derived VGVAPG hexapeptide. The palmitoyl chain dramatically enhances skin penetration through the stratum corneum and compatibility with lipid-rich, anhydrous, or oil-in-water formulations. The VGVAPG sequence activates elastin receptors on fibroblasts, stimulating tropoelastin synthesis and ECM elastin fiber production, resulting in improved skin elasticity and tone.

Main characteristics

Palmitoyl Hexapeptide-12 is the oil-compatible version of the elastin-activating VGVAPG sequence. While non-lipidated VGVAPG is primarily used in research settings, the palmitoylated version is designed specifically for cosmetic formulation compatibility. The fatty acid anchor also provides a residence effect in the lipid-rich stratum corneum, extending bioavailability. Produced via SPPS with palmitoylation to ≥95% purity (HPLC + MS).

Applications

Oil-based and anhydrous anti-aging serums and balms
Elastin-targeted firmness and elasticity formulations
Lip plumping and firmness treatments
Combination products with collagen-stimulating signal peptides
Research in elastin receptor biology and ECM fibril assembly

Technical specification

	Sequency :	Pal-VGVAPG-OH
	INCI name	Palmitoyl Hexapeptide-12
	MW :	736.98 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	171263-26-6

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB371-20mg	20 mg	254.62	305.55
SB371-50mg	50 mg	381.93	458.32
SB371-100mg	100 mg	509.25	611.10
SB371-500mg	500 mg	993.03	1191.64

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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