Acetyl Tetrapeptide-40

Anti-inflammatory tetrapeptide targeting IL-6 and IL-8 for rosacea and reactive skin calming

Acetyl Tetrapeptide-40 is a synthetic anti-inflammatory tetrapeptide that inhibits the production of pro-inflammatory interleukins IL-6 and IL-8 from skin cells, targeting the primary inflammatory mediators responsible for visible redness, erythema, and vascular reactivity. By modulating the inflammatory cascade at the cellular level, it reduces telangiectasia visibility and chronic redness associated with rosacea and couperose conditions. Highly suited for calming serums and formulations targeting reactive and sensitive skin types.

Main characteristics

Acetyl Tetrapeptide-40 acts at the cytokine production level, upstream of the visible inflammatory response. By suppressing both IL-6 (which drives fibroblast MMP production and collagen degradation) and IL-8 (a neutrophil chemoattractant), it addresses both the vascular and structural components of chronic skin inflammation. Stable at pH 4.5–7.5. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Rosacea and couperose skin serums and creams
Anti-redness formulations for reactive and sensitive skin
Post-procedure calming treatments
Formulations for telangiectasia-prone skin
Research on IL-6/IL-8 pathways in skin inflammation and inflammaging

Technical specification

	Sequency :	Ac-ATNT-OH
	INCI name	Acetyl Tetrapeptide-40
	MW :	447.20 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	1472633-28-5

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB359-20mg	20 mg	246.27	295.53
SB359-50mg	50 mg	369.41	443.29
SB359-100mg	100 mg	492.55	591.06
SB359-500mg	500 mg	960.47	1152.57

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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