Acetyl Tetrapeptide-2 / Peptigravity

Signal peptide activating elastin fiber organization, targets skin sagging and loss of firmness

Acetyl Tetrapeptide-2 (Peptigravity®) is a thymopentin-derived signal tetrapeptide that activates Fibulin-5 (FBLN5) and Lysyl Oxidase-Like 1 (LOXL1), two glycoproteins critical for elastin fiber crosslinking and organization in the extracellular matrix. By restoring ECM structural integrity and dermal-epidermal junction cohesion, it combats skin sagging and loss of firmness associated with chronological aging and gravitational forces. It also demonstrates efficacy in reducing hair loss when combined with B vitamin complexes.

Main characteristics

Acetyl Tetrapeptide-2 addresses a specific and often neglected pathway in skin aging: the progressive disorganization of elastin fibers independent of collagen degradation. By acting directly on FBLN5 and LOXL1, it restores the ECM 'scaffold' that maintains skin architecture against gravity. Stable in aqueous formulations at pH 4.5–7.0. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Lifting serums and creams targeting skin sagging and loss of contour
Anti-gravity facial and neck formulations
Treatments for jowls, cheek ptosis, and nasolabial fold reduction
Anti-hair loss scalp serums (in combination with B vitamins)
Research applications in elastin fiber biology and ECM crosslinking

Technical specification

	Sequency :	Ac-KDVY-OH
	INCI name	Acetyl Tetrapeptide-2
	MW :	565.27 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	757942-88-4

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB352-20mg	20 mg	246.27	295.53
SB352-50mg	50 mg	369.41	443.29
SB352-100mg	100 mg	492.55	591.06
SB352-500mg	500 mg	960.47	1152.57

For more information about Cosmetic Peptides, please visit our dedicated page.

Explore our Cosmetic Catalog products. Click HERE to discover additional reference compounds.

Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

Submit a Custom Request

Get a Quote