Acetyl Tetrapeptide-22

Signal peptide activating heat shock proteins for skin stress protection and barrier repair

Acetyl Tetrapeptide-22 is a synthetic signal tetrapeptide that activates heat shock protein (HSP) expression, enhancing the skin's intrinsic stress response and protein repair machinery. By upregulating HSPs, this peptide protects skin cells against UV damage, thermal stress, and oxidative insults while supporting barrier function restoration. It contributes to overall skin resilience and is suited for repair serums, barrier-restoring formulations, and environmental protection products.

Main characteristics

Heat shock proteins act as molecular chaperones, preventing protein denaturation and aggregation during cellular stress. Acetyl Tetrapeptide-22 stimulates this protective pathway, reinforcing the skin's natural defense mechanisms against daily environmental aggressors. Stable in aqueous formulations at pH 5.0–7.5. Compatible with antioxidant-rich formulation systems. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Environmental protection serums and daily UV-defense formulations
Barrier repair creams for damaged or compromised skin
Post-pollution recovery skincare
Thermal stress protection products (climate-adaptive skincare)
Research in heat shock protein biology and skin stress response

Technical specification

	Sequency :	Ac-HLLR-OH
	INCI name	Acetyl Tetrapeptide-22
	MW :	579.35 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	1295648-76-8

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB358-20mg	20 mg	246.27	295.53
SB358-50mg	50 mg	369.41	443.29
SB358-100mg	100 mg	492.55	591.06
SB358-500mg	500 mg	960.47	1152.57

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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