Palmitoyl Tripeptide-5 / Syn-Coll

Activates TGF-β pathway and collagen production

Palmitoyl Tripeptide-5 (Syn-Coll®) mimics the mechanism of Thrombospondin-1, a matricellular protein that activates latent TGF-β. By triggering TGF-β signaling in fibroblasts, it stimulates the synthesis of Collagen I and III through a pathway distinct from Matrixyl's matrikine mechanism. This mechanistic complementarity makes Syn-Coll an ideal partner rather than substitute in advanced anti-aging formulations. Clinical data show measurable improvements in skin firmness, wrinkle depth, and collagen density after 4–8 weeks of use.

Main characteristics

Palmitoyl Tripeptide-5's TGF-β activation represents an upstream approach to collagen synthesis regulation, working at the growth factor level rather than the matrikine level. Combined with Matrixyl (which acts via the matrikine pathway), the two create a multi-mechanism collagen stimulation system. The palmitoyl chain ensures stratum corneum penetration. Stable at pH 4.5–7.5. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Anti-aging collagen-boosting serums and creams
Lifting and firming formulations
Combination anti-aging systems with Matrixyl for dual collagen pathway stimulation
Research in TGF-β signaling and Thrombospondin-1 biology

Technical specification

	Sequency :	Palm-KVK-OH
	INCI name	Palmitoyl Tripeptide-5
	MW :	611.90 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	623172-56-5

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB375-20mg	20 mg	246.27	295.53
SB375-50mg	50 mg	369.41	443.29
SB375-100mg	100 mg	492.55	591.06
SB375-500mg	500 mg	960.47	1152.57

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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