Palmitoyl Tripeptide-8

Reduces neurogenic inflammation and skin discomfort

Palmitoyl Tripeptide-8 (Neutrazen™) is a lipopeptide consisting of a tripeptide linked to palmitic acid, a modification that enhances skin penetration. It has been shown to bind the MC1R receptor with an affinity similar to that of α-MSH, while exhibiting minimal melanogenic activity. In addition, Neutrazen™ helps soothe sensitive skin by reducing the production of UVB-induced pro-inflammatory cytokines, including interleukin-8 (IL-8).

Main characteristics

Palmitoyl Tripeptide-8 targets innate immune receptor signaling, a mechanism distinct from cytokine inhibitors like Palmitoyl Tetrapeptide-7 (IL-6) or neuro-soothing peptides like Skinasensyl (μ-opioid). This upstream TLR2 modulation provides broad anti-inflammatory coverage across multiple cytokine pathways. Stable at pH 4.5–7.5. Compatible with most sensitive skin formulation bases. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Sensitive and reactive skin serums and creams
Rosacea and couperose treatment formulationsù
Post-procedure and post-peel soothing products
Anti-redness and neuro-inflammatory calming treatments
Research in TLR2 innate immune signaling and skin inflammation

Technical specification

	Sequency :	Pal-HFR-OH
	INCI name	Palmitoyl Tripeptide-8
	MW :	696.92 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	936544-53-5

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB376-20mg	20 mg	351.82	422.19
SB376-50mg	50 mg	527.73	633.28
SB376-100mg	100 mg	703.64	844.37
SB376-500mg	500 mg	1372.10	1646.52

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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