Acetyl Tetrapeptide-9 / Dermican

Signal peptide activating Lumican for improved collagen fiber architecture and dermal density

Acetyl Tetrapeptide-9 is a signal peptide that activates Lumican, a small leucine-rich proteoglycan (SLRP) that plays a fundamental role in collagen fibril assembly and dermal organization. By stimulating Lumican production, this peptide improves the structural quality of the collagen fiber network, increases dermal density, and reduces the appearance of fine lines. It is especially effective for mature skin formulations where dermal thinning and loss of fibrillar collagen organization are primary concerns.

Main characteristics

Unlike signal peptides that directly stimulate collagen gene expression, Acetyl Tetrapeptide-9 works one step upstream, at the level of collagen fibril organization and crosslinking. Lumican deficiency leads to disorganized collagen fibrils and reduced skin mechanical properties; Dermican® restores this architectural function. Stable at pH 5.0–7.5. Compatible with most anti-aging serum bases. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Anti-aging serums and treatments for mature skin
Dermis-strengthening formulations targeting skin thinning
Collagen-density boosting concentrates
Post-menopausal skin care
Research in proteoglycan biology and collagen fiber assembly

Technical specification

	Sequency :	Ac-QDVH-OH
	INCI name	Acetyl Tetrapeptide-9
	MW :	539.23 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	928006-50-2

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB355-20mg	20 mg	351.82	422.19
SB355-50mg	50 mg	527.73	633.28
SB355-100mg	100 mg	703.64	844.37
SB355-500mg	500 mg	1372.10	1646.52

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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