Tetrapeptide-4

Improves extracellular matrix integrity and skin firmness

Tetrapeptide-4 (GEPG) contains a Glu-Pro-Gly collagen-like core sequence that mimics the structural repeating units of fibrillar collagens. This signal peptide activates fibroblast-mediated ECM synthesis and promotes tissue remodeling, contributing to improved skin texture, structural integrity, and firmness. The Pro-Gly sequence has high affinity for collagen-binding integrins and cell surface receptors, making it an effective signal for ECM maintenance and repair.

Main characteristics

Tetrapeptide-4's collagen-like GPG sequence provides both a structural mimicry function (fitting into collagen receptor binding sites) and a signaling function (activating fibroblast ECM production). This makes it a versatile and mechanistically grounded addition to collagen-supportive formulations. Stable in aqueous solution at pH 5.0–7.5. Compatible with most anti-aging bases. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Anti-aging collagen-supportive serums and creams
ECM repair and skin remodeling treatments
Combination signal peptide anti-aging systems
Structural skin strengthening formulations
Research in collagen-sequence peptide receptor interactions and ECM biology

Technical specification

	Sequency :	H-GEPG-OH
	INCI name	Tetrapeptide-4
	MW :	357.36 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	960608-16-6

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB381-20mg	20 mg	351.82	422.19
SB381-50mg	50 mg	527.73	633.28
SB381-100mg	100 mg	703.64	844.37
SB381-500mg	500 mg	1372.10	1646.52

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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