Dipeptide-2

Signal dipeptide for under-eye puffiness and periorbital fluid accumulation

Dipeptide-2 is a bioactive dipeptide that acts on lymphatic microcirculation in the periorbital area, improving fluid drainage and reducing interstitial accumulation responsible for under-eye puffiness. It inhibits angiotensin-converting enzyme (ACE) activity, improving local microvascular regulation and reducing vascular fluid leakage into periorbital tissue. Often combined with Eyeseryl (Acetyl Tetrapeptide-5) for synergistic eye contour benefits.

Main characteristics

Dipeptide-2's ACE inhibitory activity provides a physiological basis for its anti-puffiness effect, reducing the pressure gradient that drives interstitial fluid accumulation in the lower eyelid. It is a minimal, clean-label ingredient with a well-established bioactivity profile. Stable in aqueous solution and compatible with most eye contour formulation bases.

Applications

Eye contour serums targeting under-eye bags and puffiness
Combination eye treatments with Eyeseryl (Acetyl Tetrapeptide-5)
Anti-edema facial formulations
Periorbital drainage and refreshing eye gels
Research on ACE inhibitory peptides and lymphatic microcirculation

Technical specification

	Sequency :	H-VW-OH
	INCI name	Dipeptide-2
	MW :	303.15 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	24587-37-9

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB361-20mg	20 mg	246.27	295.53
SB361-50mg	50 mg	369.41	443.29
SB361-100mg	100 mg	492.55	591.06
SB361-500mg	500 mg	960.47	1152.57

For more information about Cosmetic Peptides, please visit our dedicated page.

Explore our Cosmetic Catalog products. Click HERE to discover additional reference compounds.

Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

Submit a Custom Request

Get a Quote