Nonapeptide-1

Competitive α-MSH antagonist at MC1R receptor for targeted melanogenesis inhibition

Nonapeptide-1 is a synthetic biomimetic peptide that acts as an α-MSH antagonist by binding to MC1R receptors on melanocytes. By reducing the signaling pathway involved in melanogenesis, it helps decrease melanin production and promote a more even skin tone. Nonapeptide-1 provides effective skin-brightening benefits without affecting melanocyte viability or normal cellular functions.

Main characteristics

Nonapeptide-1's ultra-low IC50 (2.5 nM) makes it one of the most potent melanogenesis inhibitors available for cosmetic use. Its receptor-level specificity means it interferes with the hormonal trigger of pigmentation rather than enzymatic activity, providing clean, targeted brightening without melanocyte toxicity. Stable in aqueous formulations at pH 4.5–7.0. Produced via SPPS to ≥95% purity (HPLC + MS).

Applications

Brightening and skin-tone-evening serums and creams
Melasma and UV-induced hyperpigmentation treatments
Combination products with Decapeptide-12 for dual-mechanism depigmentation
Research in MC1R pharmacology and melanocortin signaling

Technical specification

	Sequency :	H-MPFRWFKPV-NH2
	INCI name	Nonapeptide-1
	MW :	1206.51 g/mol
	Purity :	> 95%
	Counter-Ion :	TFA Salts
	Delivery format :	Lyophilized
	CAS number :	158563-45-2

TFA removal service available (acetate or HCl exchange)

Price

Product	Size	Price €	Price $
SB365-20mg	20 mg	339.67	407.60
SB365-50mg	50 mg	509.50	611.40
SB365-100mg	100 mg	679.34	815.20
SB365-500mg	500 mg	1324.71	1589.65

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Custom Cosmetic Peptides Services

If your target is not listed, we offer custom Cosmetic Peptides design and synthesis. Whether you require sequence optimization, specific modifications, or larger production quantities, our team can support your project. Submit your project details and we will provide a personalized proposal.

Analytical Documentation Included
A Certificate of Analysis (CoA), MS analysis, and HPLC purity report are provided with every batch.

Research Use Only
For research and laboratory use only. Not for human consumption or therapeutic use.

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