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HsTx1

HsTx1 – Ion Channels and Transporters HsTx-1 is a member of the a-KTx6 family of scorpion toxins active on voltage-gated Kv1.3 channels (Kd close to 10 pM). HsTx-1 is also very active on Kv1.1 channels (IC50 around 7 nM). It is however inactive on...

Hm1a

Hm1a – Ion Channels and Transporters Hm1a has been identified from the venom of the spider Heteroscodra maculata. Hm1a has been described as a potent and selective agonist of the voltage-gated sodium channel Nav1.1 with an EC value of 38 nM. Nav1.1 is expressed...

Hainantoxin-IV

Hainantoxin-IV – Ion Channels and Transporters Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spider Ornithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a...

Hainantoxin-III

Hainantoxin-III – Ion Channels and Transporters Hainantoxin-III (HNTX-III; hainantoxin-3) is a peptide that has been isolated from the venom of the Chinese bird spider Seleconosmia hainana. Hainantoxin-III specifically blocks mammalian neuronal...

Guangxitoxin-1E

Guangxitoxin-1E – Ion Channels and Transporters Guangxitoxin-1E (GxTx-1E) was isolated from the venom of Chilobrachys jingzhao (Chinese earth tiger tarantula). Guangxitoxin-1E was shown to block Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3 channels without...